Mitochondrial Respiratory Chain Enzyme Activities, mtDNA Variants and Gene Expression Levels in Idiopathic Parkinson's Disease

ERCAN, AYŞE; KULAKSIZ, Gulnihal; Dalmizrak, ÖZLEM; Muftuoglu, MELTEM; OGUS, Hamdi; CAVDAR, Leyla; INAN, Levent; Ozer, NAZMİ

Mitochondrial Respiratory Chain Enzyme Activities, mtDNA Variants and Gene Expression Levels in Idiopathic Parkinson's Disease

Copy For Citation

ERCAN A., KULAKSIZ G., Dalmizrak O., Muftuoglu M., OGUS H., CAVDAR L., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.34, no.2, pp.97-104, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 34 Issue: 2
Publication Date: 2009
Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.97-104
Hacettepe University Affiliated: Yes

Abstract

Purpose: Mitochondrial dysfunction has been implicated in the development of idiopathic Parkinson's disease. In this study, it was aimed to investigate the relationship between mitochondrial respiratory chain enzyme deficiency and variants in ND2 and ND4 region of Complex I and expressions of these genes. Complex IV activity and glutathione level were also studied.