Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats

Sanli, Ahmet; Serbes, Gokhan; SARGON, MUSTAFA; ÇALIŞKAN, MURAT; Kilinc, Kamer; Bulut, Husamettin; Sekerci, Zeki

doi:10.1007/s00701-012-1302-8

Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats

Sanli A. M., Serbes G., SARGON M. F., ÇALIŞKAN M., Kilinc K., Bulut H., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.154, sa.6, ss.1045-1054, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 154 Sayı: 6
Basım Tarihi: 2012
Doi Numarası: 10.1007/s00701-012-1302-8
Dergi Adı: ACTA NEUROCHIRURGICA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1045-1054
Hacettepe Üniversitesi Adresli: Evet

Özet

The goal of most acute therapies for spinal cord injury (SCI) in humans include attenuation of the early inflammatory response and may limit the extent of tissue injury and the consequent disability.