Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats

Sanli, Ahmet; Serbes, Gokhan; SARGON, MUSTAFA; ÇALIŞKAN, MURAT; Kilinc, Kamer; Bulut, Husamettin; Sekerci, Zeki

doi:10.1007/s00701-012-1302-8

Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats

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Sanli A. M., Serbes G., SARGON M. F., ÇALIŞKAN M., Kilinc K., Bulut H., ...More

ACTA NEUROCHIRURGICA, vol.154, no.6, pp.1045-1054, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 154 Issue: 6
Publication Date: 2012
Doi Number: 10.1007/s00701-012-1302-8
Journal Name: ACTA NEUROCHIRURGICA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1045-1054
Hacettepe University Affiliated: Yes

Abstract

The goal of most acute therapies for spinal cord injury (SCI) in humans include attenuation of the early inflammatory response and may limit the extent of tissue injury and the consequent disability.