Associations between pediatric intensive care procedures and urinary free-BPA levels

Ayar G., YALÇIN S. S., Yirun A., Emeksiz S., Balci A., ERKEKOĞLU Ü. P.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, cilt.29, sa.9, ss.13555-13563, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11356-021-16677-2
  • Dergi Adı: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, IBZ Online, ABI/INFORM, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Environment Index, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.13555-13563
  • Anahtar Kelimeler: Child, Free bisphenol A, Medical equipment, Paediatric intensive care unit, Total bisphenol A, TOTAL BISPHENOL-A, EXPOSURE, HUMANS, PLASTICIZER, METABOLISM
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background Bisphenol A (BPA) is found in many medical materials used in the paediatric intensive care unit (PICU). Our aim was to evaluate how the urinary free-BPA(fBPA) and total-BPA(tBPA) levels were associated with the use of medical devices in the PICU in a prospective study. Methods The procedures applied to the patient were recorded during the follow-up period. Three urine samples were taken on the first day of hospitalization; the seventh day, and after 30 days or when the patients were discharged. Urinary tBPA and fBPA levels were determined using high-pressure liquid chromatography. Generalized estimating equations with repetitive measures were used to determine the associations between PICU procedures and BPA levels. Results A total of 115 urine samples of 40 children were studied. Mean urinary levels were 189.2 mu g/g-creatinine for tBPA and 27.8 mu g/g-creatinine for fBPA, and the fBPA/tBPA ratio was 27.9%. Endotracheal intubation, catheter, and haemodialysis procedures caused higher urinary fBPA levels. External drains, inhaler treatment, and the use of four or more medical devices were associated with considerably higher values of fBPA%. The increase in tBPA was positively correlated with fBPA. Conclusions fBPA levels and the fBPA/tBPA ratio varied according to the procedure and level of BPA exposure in children.