In vivo half life of nanoencapsulated L-asparaginase

Baran E., Ozer N., Hasirci V.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol.13, no.12, pp.1113-1121, 2002 (SCI-Expanded) identifier identifier


In the present study, antileukemic enzyme L-asparaginase (ASNase) was encapsulated into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules in order to decrease the immunogenicity and toxicity of the enzyme and to increase its in vivo half life in mice.