Metabolomics analysis insight into medicinal plant science

Waris M., Kocak E., Gonulalan E. M., DEMİREZER L. Ö., KIR S., NEMUTLU E.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, cilt.157, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 157
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.trac.2022.116795
  • Dergi Adı: TRAC-TRENDS IN ANALYTICAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Analytical Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, Food Science & Technology Abstracts, DIALNET
  • Anahtar Kelimeler: Metabolomics, Medicinal plant, GC-MS, LC-MS, NMR, Imaging, Spatial distribution, SOLID-PHASE MICROEXTRACTION, SPECTROMETRY-BASED METABOLOMICS, LASER-DESORPTION-IONIZATION, MASS-SPECTROMETRY, ARABIDOPSIS-THALIANA, GC, METABOLITES, LEAVES, GC/MS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The plant-based metabolomics studies are increasing rapidly to identify new active compounds, deter-mine the vegetation period, investigate adulteration, evaluate correlation activity and metabolite levels, and monitor quality control of medicinal plants. Despite remarkable technological advances in metab-olite separation and analysis, the chemical differences of primary and secondary metabolites of complex natural products present extraordinary challenges for analysis. The difficulties in plant metabolomics studies range from sample collection to preparation and continue from analysis to metabolite annotation and quantification. A comprehensive metabolomics analysis evaluation of current and new trends in plant metabolomics will guide researchers holistically in designing their research. Therefore, in this review, all necessary steps (extraction strategies, sample preparation, data acquisition and pre-processing, and metabolite annotation) to effectively complete plant metabolomics studies using different analytical platforms (nuclear magnetic resonance, gas chromatography-mass spectrometry, and liquid chromatography-high-resolution mass spectrometry) were evaluated.(c) 2022 Elsevier B.V. All rights reserved.