Cytotoxic Compounds from Endemic Arnebia purpurea

Yuzbasioglu M., Kuruuzum-Uz A., GÜVENALP Z., SIMON A., TOTH G., Harput U. S., ...Daha Fazla

NATURAL PRODUCT COMMUNICATIONS, cilt.10, sa.4, ss.595-596, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 4
  • Basım Tarihi: 2015
  • Dergi Adı: NATURAL PRODUCT COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.595-596
  • Anahtar Kelimeler: Arnebia purpurea, Boraginaceae, Naphthoquinones, Flavonoids, Triterpenes, Steroids, Rosmarinic acid, Cytotoxicity, ANTIOXIDANT, SHIKONIN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), alpha-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [beta-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5 ''-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rutinoside, and kaempferol 3-O-(5 ''-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.