The effect of mannose-binding protein gene polymorphisms in recurrent respiratory system infections in children and lung tuberculosis


Ozbas-Gerceker F., Tezcan I., Berkel A., Ozkara S., Ozcan A., Ersoy F., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.45, ss.95-98, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 2
  • Basım Tarihi: 2003
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Sayfa Sayıları: ss.95-98

Özet

Mannose-binding lectin (MBL) is Able to bind pathogens as an opsonin and plays an important role in the innate immunity. The aim of the present study was to determine the frequencies of the MBL gene variants in the Turkish population and to examine the presence of any association between MBL variants and development of tuberculosis (TB) in adults and recurrent respiratory tract infections in children. Two structural gene mutations in exon 1 of MBL gene (codon 54 and codon 57) were: studied. The overall distribution of genotypes did not significantly differ between controls and TB patients/ children with recurrent respiratory system infections.