Selective cytotoxic and cytostatic activity of some phenypropanoid glycosides

SARAÇOĞLU İ., Calis I., Inoue M., Ogihara Y.

Fitoterapia, cilt.68, sa.5, ss.434-438, 1997 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 5
  • Basım Tarihi: 1997
  • Dergi Adı: Fitoterapia
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.434-438
  • Anahtar Kelimeler: Cytostatic activity, Cytotoxicity, Phenylpropanoid glycosides
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The cytotoxic and cytostatic activity of angoroside A, angoroside B, angoroside C, poliumoside and (+)-syringaresinol O-β-D-glucopyranoside were investigated by the dye exclusion method using 3-[4,5-dimethylthiazol-2-yl]- 2,5-diphenyltetrazolium bromide (MTT). Caffeic acid-containing phenylpropanoid glycosides were found to exhibit activity against several kinds of cancer cells. However, they did not affect the growth and viability of primary-cultured rat hepatocytes. Study of the structure-activity relationship indicated that ortho-dihydroxy aromatic systems of phenylpropanoid glycosides are necessary for their cytotoxic and cytostatic activities.