Selective cytotoxic and cytostatic activity of some phenypropanoid glycosides


SARAÇOĞLU İ., Calis I., Inoue M., Ogihara Y.

Fitoterapia, vol.68, no.5, pp.434-438, 1997 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 1997
  • Journal Name: Fitoterapia
  • Journal Indexes: Scopus
  • Page Numbers: pp.434-438
  • Keywords: Cytostatic activity, Cytotoxicity, Phenylpropanoid glycosides

Abstract

The cytotoxic and cytostatic activity of angoroside A, angoroside B, angoroside C, poliumoside and (+)-syringaresinol O-β-D-glucopyranoside were investigated by the dye exclusion method using 3-[4,5-dimethylthiazol-2-yl]- 2,5-diphenyltetrazolium bromide (MTT). Caffeic acid-containing phenylpropanoid glycosides were found to exhibit activity against several kinds of cancer cells. However, they did not affect the growth and viability of primary-cultured rat hepatocytes. Study of the structure-activity relationship indicated that ortho-dihydroxy aromatic systems of phenylpropanoid glycosides are necessary for their cytotoxic and cytostatic activities.