Research Information System
BioNanoScience, vol.16, no.4, 2026 (ESCI, Scopus)
Wound dressing materials play a vital role in accelerating the healing process. Conventional wound coverings, such as gauze and bandages, frequently do not establish an ideal healing environment. However, electrospun nanofibrous materials offer captivating opportunities due to their unique attributes. Historically, wound management and recovery were laborious process. Fortunately, as technology progresses, modern and durable treatments are being developed to facilitate healing. This study aims to produce and analyze nanofibers made of hydroxypropylcellulose (HPC) and graphene using the electrospinning technique, while also investigating their potential for drug release. The morphology, chemical structure, crystal structure, and thermal behavior of the HPC-graphene nanofibers were characterized using SEM, FT-IR/ATR, XRD, and TGA-DSC. Scanning electron microscope (SEM) images demonstrated consistent, uniform, and bead-free nanofiber morphology. The mean diameter of HPC-graphene nanofibers was determined to be 186 nm. We carried out the in vitro drug release studies separately in two different buffer systems to see how well the nanofibers worked under different physiological conditions. The 24-hour tests showed that the nanofibers released 85% of the terramycin in a pH 7.4 environment, while a different test in a pH 4.5 environment showed that they released 63% of the terramycin. Nanofiber-based drug delivery systems demonstrate significant promise in various domains, including drug release, tumor therapy, wound dressing, and tissue engineering. Nevertheless, it is crucial to acknowledge that the utilization of nanofibers for drug delivery remains a dynamic field of investigation and may not yet be applicable to all medications or diseases.