Acute lymphoblastic leukemia in infants

Gurgey A., Yetgin S., Cetin M., Gumruk F., Tuncer A., Tuncbilek E., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.46, no.2, pp.115-119, 2004 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2004
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.115-119


Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two-or three-drug induction with prednisolone, vincristine and L-asparaginase, and maintenance therapy consisted of weekly oral administration of mercaptopurine and methotrexate for three years. Group 2: Between 1991 and 1999, 11 infants with ALL were treated by St. Jude Total Therapy XI (n = 4) and XIII (n = 7) protocols with minor modification. Three years' event-free survival (SE) was 14+/-9% in group 1. In group 2, this rate was 25+/-22% in Total XI and 57+/-19% in Total XIII. Outcome for infants on protocols Total Therapy XI and XIII improved compared with that of group 1.