Acute lymphoblastic leukemia in infants

Gurgey A. , Yetgin S. , Cetin M., Gumruk F., Tuncer A., Tuncbilek E. , ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.46, sa.2, ss.115-119, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Konu: 2
  • Basım Tarihi: 2004
  • Sayfa Sayıları: ss.115-119


Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two-or three-drug induction with prednisolone, vincristine and L-asparaginase, and maintenance therapy consisted of weekly oral administration of mercaptopurine and methotrexate for three years. Group 2: Between 1991 and 1999, 11 infants with ALL were treated by St. Jude Total Therapy XI (n = 4) and XIII (n = 7) protocols with minor modification. Three years' event-free survival (SE) was 14+/-9% in group 1. In group 2, this rate was 25+/-22% in Total XI and 57+/-19% in Total XIII. Outcome for infants on protocols Total Therapy XI and XIII improved compared with that of group 1.