Acute lymphoblastic leukemia in infants

Gurgey A., Yetgin S., Cetin M., Gumruk F., Tuncer A., Tuncbilek E., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.46, sa.2, ss.115-119, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 2
  • Basım Tarihi: 2004
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.115-119
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two-or three-drug induction with prednisolone, vincristine and L-asparaginase, and maintenance therapy consisted of weekly oral administration of mercaptopurine and methotrexate for three years. Group 2: Between 1991 and 1999, 11 infants with ALL were treated by St. Jude Total Therapy XI (n = 4) and XIII (n = 7) protocols with minor modification. Three years' event-free survival (SE) was 14+/-9% in group 1. In group 2, this rate was 25+/-22% in Total XI and 57+/-19% in Total XIII. Outcome for infants on protocols Total Therapy XI and XIII improved compared with that of group 1.