Rational use of the PFA-100 device for screening of platelet function disorders and von Willebrand disease
BLOOD COAGULATION & FIBRINOLYSIS, vol.13, no.4, pp.349-353, 2002 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 13 Issue: 4
- Publication Date: 2002
- Doi Number: 10.1097/00001721-200206000-00011
- Journal Name: BLOOD COAGULATION & FIBRINOLYSIS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.349-353
- Hacettepe University Affiliated: Yes
Abstract
Two hundred and five patients referred for evaluation of platelet functions and 126 healthy controls were tested with the PFA-100 instrument. A cut-off value of 150 s for collagen/epinephrine (CEPI) closure time (CT) produced most acceptable sensitivity (90%), specificity (85.2%), and positive (82.6%) and negative (91.6%) predictivity values for screening of platelet function disorders and von Willebrand disease (vWD). All patients with vWD and Glanzmann thrombasthenia could be detected by PFA-100. Both CEPI and collagen/adenosine diphosphate (CADP) CTs were elevated in all of these cases. Sensitivity of the device was 81.6% for patients with platelet secretion defects. CADP CT was normal in 63.9% of the patients in this subgroup. Specificity (47%) and positive predictivity (57%) of the instrument were diminished in patients with low hemoglobin concentrations. Depending on the results, an algorithm was developed for screening of platelet function disorders and vWD with PFA-100.