JOURNAL OF PEDIATRIC INFECTION, cilt.11, sa.2, 2017 (ESCI)
This study presents an overview of the scientific and ethical issues pertaining to the most controversial areas of experimentation on humans (research with children subjects, risk/benefit estimation in paediatric research maturity of children to consent to medical research). Over the past decade, the questions regarding research ethics related to this issue have continuously evolved. The major objective of this paper is that each of these issues will continue to pose new ethical questions and mechanisms in relevant areas for ongoing considerations of these questions. It is essential that we are aware of the ethical issues in various paediatric research studies an continue to search for answers for the numerous ethical challenges, being aware of the vulnerability/defenselessness and capacity development of child participants.