Comparative effects of methylprednisolone and tetracosactide (ACTH(1-24)) on ischemia/reperfusion injury of the rabbit spinal cord

Creative Commons License

Kertmen H., Celikoglu E., Ozturk O. C., Gurer B., BOZKURT H., Kanat M. A., ...More

ARCHIVES OF MEDICAL SCIENCE, vol.14, no.6, pp.1459-1470, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.5114/aoms.2017.65650
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1459-1470
  • Hacettepe University Affiliated: Yes

Abstract

Introduction: Tetracosactide is an engineered peptide that applies the same biological impacts as the endogenous adrenocorticotropic hormone. Previous studies indicated that tetracosactide has anti-inflammatory, antioxidant and neurotrophic activity. In this study, we hypothesized that tetracosactide may have protective effects in spinal cord ischemia-reperfusion injury.