Acetylsalicylic Acid Loading and Release Studies of the PMMA-g-Polymeric Oils/Oily Acids Micro and Nanospheres

KILIÇAY E., ÇAKMAKLI B., HAZER B., DENKBAŞ E. B., AÇIKGÖZ B.

JOURNAL OF APPLIED POLYMER SCIENCE, vol.119, no.3, pp.1610-1618, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 119 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1002/app.32825
  • Journal Name: JOURNAL OF APPLIED POLYMER SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1610-1618
  • Hacettepe University Affiliated: No

Abstract

Poly(methyl methacrylate) (PMMA) and PMMA copolymers derived from plant oils (Polylinseed oil-g-PMMA, Polysoybean oil-g-PMMA, Polylinoleic acid-g-PMMA (PLina-g-PMMA) and Polyhydroxy alkanoate-sy-g-Polylinoleic acid-g-PMMA (PHA-g-PLina-g-PMMA)) as hydrophobic polymers, a series of hydrophobic microsphere or nanosphere dispersions, were prepared by the emulsion/solvent evaporation method. The diameters of the nanospheres and microspheres were measured by dynamic light scattering with a zetasizer, optically and by scanning electron microscopy. The magnetic quality of the microspheres was determined by the electron spin resonance technique. Acetylsalicylic acid (aspirin, ASA) was used as a model drug and loaded into the microspheres during the preparation process. The effect of the stirring rate over the size and size distribution of the micro/nanospheres was evaluated, and the effects of copolymer types derived from plant oil/oily acids and the copolymer/drug ratios were evaluated. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 1610-1618, 2011