Organelle Positioning in Neurons and Skeletal Muscle Cells

AKSU MENGEŞ E., KURAL MANGIT E., Bekircan-Kurt C. E., BORA G.

GAZI MEDICAL JOURNAL, vol.32, pp.341-347, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 32
  • Publication Date: 2021
  • Doi Number: 10.12996/gmj.2021.79
  • Journal Name: GAZI MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Page Numbers: pp.341-347
  • Hacettepe University Affiliated: Yes

Abstract

Organelles are dynamic compartments, whose spatial positions are tightly regulated for cellular functions. An increasing number of studies have shown dysregulations in organelle positions, especially in muscular and neurological diseases, therefore understanding the basic mechanisms of organelle positioning could help to develop new therapeutic strategies. In this review, we focused on the mechanisms of organelle positioning in two specialized cells, muscle and nerve, as well as the contribution of mispositioning to disease pathomechanisms.