Modeling the spreading cortical depression wavefront


Baysal U., Haueisen J.

VISUALIZATION AND IMAGING IN TRANSPORT PHENOMENA, cilt.972, ss.127-132, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 972
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1111/j.1749-6632.2002.tb04562.x
  • Dergi Adı: VISUALIZATION AND IMAGING IN TRANSPORT PHENOMENA
  • Sayfa Sayıları: ss.127-132

Özet

Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2-5 mm/min and is followed by a 5-10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain surfaces. The usefulness of the technique is demonstrated on a rat brain that had been segmented from a three-dimensional magnetic resonance image data set. With the help of this methodology it is possible to create specific patient models to better understand the mechanisms of SCD.