THERAPEUTIC AND GENETIC-ASPECTS OF CONGENITAL GLAUCOMAS


TURACLI M., AKTAN S., SAYLI B., AKARSU N.

INTERNATIONAL OPHTHALMOLOGY, vol.16, pp.359-362, 1992 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 1992
  • Title of Journal : INTERNATIONAL OPHTHALMOLOGY
  • Page Numbers: pp.359-362

Abstract

Therapy for congenital glaucoma is primarily surgical. We have investigated 249 cases who have undergone trabeculectomy. There was a 79% success rate as regards to control of the IOP. Vision could be saved among the patients who had applied relatively early. At the end of the follow up which was 5 years IOP remained normal in the successful group. All the patients and their families were analysed genetically by their pedigrees and caryotypes. An autosomal recessive pattern with variable penetrance was found. The majority of the patients came from families with consanguineous marriages giving a rate of 66.6%. It was suggested that the course of the disease is highly affected by and related to parental consanguinity. An early age of onset and an accelerated clinical course could be well correlated.