HIGH-DOSE ANTICHOLINERGIC THERAPY (BIPERIDEN) IN DYSTONIA

OZTEKIN N., SAYGI S., DALKARA T., SENSES I., ZILELI T.

CLINICAL NEUROLOGY AND NEUROSURGERY, vol.93, no.1, pp.35-37, 1991 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 93 Issue: 1
  • Publication Date: 1991
  • Doi Number: 10.1016/0303-8467(91)90006-b
  • Journal Name: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.35-37
  • Keywords: ANTICHOLINERGICS, TORSION DYSTONIA, TORSION DYSTONIAS
  • Hacettepe University Affiliated: Yes

Abstract

We studied the effect of biperiden in the treatment of dystonia in six patients aged 15-30 years. Five patients had generalized and one patient had segmental dystonia. Biperiden was started at a dose of 2 mg/day and was gradually increased to 40 mg/day in a few weeks. All patients had clinically significant response in varying degrees after a mean follow up of 1.9 years. Three patients showed considerable or dramatic benefit. The 40 mg/day was generally well tolerated. High dose anticholinergic therapy is effective in the management of torsion dystonia.