Influence of video display terminal use and meibomian gland dysfunction on the ocular surface and tear neuromediators

Bilgic A. A., KOCABEYOĞLU S., DİKMETAŞ Ö., TAN Ç., KARAKAYA KARABULUT J., Irkec M.

INTERNATIONAL OPHTHALMOLOGY, cilt.43, sa.5, ss.1537-1544, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 5
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10792-022-02549-2
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1537-1544
  • Anahtar Kelimeler: Evaporative dry eye, Video display terminal, Meibomian gland dysfunction, In vivo confocal microscopy, Tear neuromediators, Substance P, DRY EYE DISEASE, CORNEAL INNERVATION, SUBSTANCE-P, MORPHOLOGY, CYTOKINES, BLINKING, NERVES, FILM
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective To evaluate the effects of video display terminal (VDT) work and meibomian gland dysfunction (MGD) on ocular surface parameters, tear cytokine and substance P (SP) levels, and their association with dry eye disease (DED). Methods This cross-sectional study included 60 patients with evaporative DED and 20 healthy individuals. The DED patients were divided into three groups according to daily VDT work time and presence of MGD. The ocular surface and tear film were assessed using the Ocular Surface Disease Index questionnaire (OSDI), tear film break-up time (TBUT), ocular surface staining, Schirmer II test, and corneal sensitivity. MGD was evaluated with meibography. Corneal nerve alterations were evaluated using in vivo confocal microscopy (IVCM). The tear levels of 30 cytokines and SP were examined. Results Compared to controls, DED patients had higher OSDI score (p < 0.001), increased corneal staining with fluorescein and lissamine green (p = 0.046, p = 0,038), and lower TBUT (p < 0.001). Tear interleukin-6 levels were higher in DED patients, while tear SP levels did not differ between the groups (p = 0.265). VDT work time showed a weak positive correlation with OSDI (r = 0.274, p = 0.014) and SP level (r = 0.284, p = 0.011). Conclusion The results of this study show that VDT use and MGD have an adverse effect on the ocular surface. It was also observed that the combination of VDT use and MGD did not significantly increase the ocular surface disease, but longer VDT exposure may be associated with more complaints of ocular discomfort.