In this sudy, it has been researched for the first time of two new genus honey type, which were visited by honeybees. These genuses are Euphorbia (Euphorbiaceae family) (spurge or milkweed honey) and Verbascum (Scrophulariaceae family) (mullein honey). First of all mellissopalynological examinations determined and then total phenolic and total flavonoid capacity, sugar composition and chemical compouns found. Total phenolic acid content was determined as 146.49 0.11 mgGAE/kg for mullein honey and 136.92 0.06 mgGAE/kg for spurge honey. Total flavonoid content was determined as 35.54 0.05 mgQE/kg for mullein honey and 40.68 0.03 mgQE/kg for spurge honey. The results of sugar analysis performed by HPLC show that, Fructose 45.7%, Glucose 24.8% and F/G rate was 1.84 0.17 for mullein honey and Fructose 38%, Glucose 28.5% and F/G rate was 1.33 0.02 for spurge honey. GC-MS analysis of honey samples revealed alcohols, carboxylic acids and their esters, fatty acids, flavonoids, carbohydrates, ketones, terpenes and other chemical compounds. To the best of our knowledge, this was the first study about spurge and mullein monofloral honeys.