Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation

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ŞATIRER Ö., Zeytin I. C., Alkan B., KARAKAYA KARABULUT J., ÇETİNKAYA F. D., OKUR F. V.

TURKISH JOURNAL OF HEMATOLOGY, cilt.39, sa.1, ss.61-65, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/tjh.galenos.2021.2021.0434
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.61-65
  • Anahtar Kelimeler: Graft-versus-host disease, Angiopoietin-2, Angiogenesis, Inflammation, Hematopoietic stem cell transplantation, NONRELAPSE MORTALITY, ANGIOGENIC FACTORS, BIOMARKERS, DIAGNOSIS, DAMAGE, COMPLICATIONS, INFLAMMATION, SEVERITY, BLOOD, VEGF
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Angiogenic factors (AFs) released under endothelial stress are reflective of tissue healing, while some may also contribute to tissue damage/inflammation. We investigated whether alterations in the pre-transplant levels of AFs were associated with the risk of acute graft-versus-host disease (aGvHD). Materials and Methods: The pre-conditioning plasma levels of angiopoietin-2 (Ang2), endoglin, and follistatin were measured for 37 patients together with inflammatory markers. The index values defined were evaluated to better identify the alterations. Results: The patients had higher pre-conditioning levels of Ang2, endoglin, and follistatin compared to controls. The patients with aGvHD had higher Ang2 index and lower albumin index scores in comparison to those without aGvHD. Multivariate analysis revealed that the pre-transplant Ang2 index was an independent risk factor for aGvHD development. Conclusion: Pre-transplant evaluation of plasma Ang2 levels along with inflammatory status even before conditioning is associated with endothelial vulnerability. The pre-transplant Ang2 index could be a promising candidate to estimate the risk of aGvHD.