Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C

TÜRKMEN D., BERELİ N., CORMAN M. E., SHAIKH H., AKGÖL S., DENİZLİ A.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.42, sa.5, ss.316-322, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/21691401.2013.823094
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.316-322
  • Anahtar Kelimeler: mitomycin C delivery, molecular imprinting, nanoparticles, PHEMA, ANTICANCER DRUG 5-FLUOROURACIL, CONTROLLED-RELEASE, POLYMERS, MICROSPHERES, RECOGNITION, HYDROGELS, NANOSPHERES, SEPARATION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Controlled drug delivery system is a technique which has considerable recent potential in the fields of pharmacy and medicine. Mitomycin C is commonly used drug in the treatment of superficial bladder and breast cancers. In the present study, mitomycin C-imprinted magnetic poly(hydroxyethyl methacrylate)-based nanoparticles (MIMNs) were prepared using surfactant free emulsion polymerization for controlled delivery of mitomycin C. The MIMNs were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, electron spin resonance, and elemental analysis. The average particle diameter of MIMNs was about 200 nm.