Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C

TÜRKMEN D., BERELİ N., CORMAN M. E., SHAIKH H., AKGÖL S., DENİZLİ A.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, vol.42, no.5, pp.316-322, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.3109/21691401.2013.823094
  • Journal Name: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.316-322
  • Keywords: mitomycin C delivery, molecular imprinting, nanoparticles, PHEMA, ANTICANCER DRUG 5-FLUOROURACIL, CONTROLLED-RELEASE, POLYMERS, MICROSPHERES, RECOGNITION, HYDROGELS, NANOSPHERES, SEPARATION
  • Hacettepe University Affiliated: Yes

Abstract

Controlled drug delivery system is a technique which has considerable recent potential in the fields of pharmacy and medicine. Mitomycin C is commonly used drug in the treatment of superficial bladder and breast cancers. In the present study, mitomycin C-imprinted magnetic poly(hydroxyethyl methacrylate)-based nanoparticles (MIMNs) were prepared using surfactant free emulsion polymerization for controlled delivery of mitomycin C. The MIMNs were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, electron spin resonance, and elemental analysis. The average particle diameter of MIMNs was about 200 nm.