Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model

Yagci, Ramazan; Oflu, Yusuf; Yagci, Server; Dincel, Aysun; Kaya, Esma; Duman, Sunay; Bozkurt, ATİLLA

doi:10.1016/j.curtheres.2007.06.003

Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model

Yagci R., Oflu Y., Yagci S., Dincel A., Kaya E., Duman S., ...Daha Fazla

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, cilt.68, sa.3, ss.184-190, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 68 Sayı: 3
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.curtheres.2007.06.003
Dergi Adı: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.184-190
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Bacterial endophthalmitis is a serious complication of ocular surgery and penetrating trauma. The primary causative organisms are strains of Staphylococcus aureus and Staphylococcus epidermidis. Fluoroquinolones are widely used to treat endophthalmitis. There are a few studies on the penetration of fluoroquinolones into the lens in inflamed eyes. A literature search did not identify any data regarding penetration of topical ofloxacin into the lens in normal and inflamed eyes.