Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model

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Yagci R., Oflu Y., Yagci S., Dincel A., Kaya E., Duman S., ...More

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.68, no.3, pp.184-190, 2007 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 68 Issue: 3
• Publication Date: 2007
• Doi Number: 10.1016/j.curtheres.2007.06.003
• Journal Name: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.184-190
• Hacettepe University Affiliated: Yes

Abstract

Background: Bacterial endophthalmitis is a serious complication of ocular surgery and penetrating trauma. The primary causative organisms are strains of Staphylococcus aureus and Staphylococcus epidermidis. Fluoroquinolones are widely used to treat endophthalmitis. There are a few studies on the penetration of fluoroquinolones into the lens in inflamed eyes. A literature search did not identify any data regarding penetration of topical ofloxacin into the lens in normal and inflamed eyes.