Lens concentration of ofloxacin and lomefloxacin in an experimental endophthalmitis model

Yagci R., Oflu Y., Yagci S., Dincel A., Kaya E., Duman S., ...More

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.68, no.3, pp.184-190, 2007 (SCI-Expanded) identifier identifier


Background: Bacterial endophthalmitis is a serious complication of ocular surgery and penetrating trauma. The primary causative organisms are strains of Staphylococcus aureus and Staphylococcus epidermidis. Fluoroquinolones are widely used to treat endophthalmitis. There are a few studies on the penetration of fluoroquinolones into the lens in inflamed eyes. A literature search did not identify any data regarding penetration of topical ofloxacin into the lens in normal and inflamed eyes.