Inkjet printing of antiviral PCL nanoparticles and anticancer cyclodextrin inclusion complexes on bioadhesive film for cervical administration

VARAN C., WİCKSTRÖM H., SANDLER N., AKTAŞ Y., BİLENSOY E.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol.531, no.2, pp.701-713, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 531 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ijpharm.2017.04.036
  • Journal Name: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.701-713
  • Keywords: Cidofovir, Cyclodextrin, Fixed dose combination, Inkjet printing, Nanoparticle, Paclitaxel, PHASE-II TRIAL, DRUG-DELIVERY, INTRAVESICAL CHEMOTHERAPY, LOADED NANOPARTICLES, PACLITAXEL, CANCER, SOLUBILITY, CISPLATIN, EFFICACY, THERAPY
  • Hacettepe University Affiliated: Yes

Abstract

Personalized medicine is an important treatment approach for diseases like cancer with high intrasubject variability. In this framework, printing is one of the most promising methods since it permits dose and geometry adjustment of the final product. With this study, a combination product consisting of anticancer (paclitaxel) and antiviral (cidofovir) drugs was manufactured by inkjet printing onto adhesive film for local treatment of cervical cancers as a result of HPV infection. Furthermore, solubility problem of paclitaxel was overcome by maintaining th` is poorly soluble drug in a cyclodextrin inclusion complex and release of cidofovir was controlled by encapsulation in polycaprolactone nanoparticles. In vitro characterization studies of printed film formulations were performed and cell culture studies showed that drug loaded film formulation was effective on human cervical adenocarcinoma cells.