Microbiological and clinical comparison of chlorhexidine buccoadhesive tablet and chlorhexidine mouthrinse


AKTAŞ A. , GIRAY B., ÇAPAN Y. , MENEMENLIOGLU D. , HAYRAN M. , IKINCI G. , ...Daha Fazla

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.19, ss.353-357, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 19 Konu: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/s1773-2247(09)50073-1
  • Dergi Adı: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Sayfa Sayıları: ss.353-357

Özet

Chlorhexidine, which is a gold standard for antiplaque agents, was prepared (is a buccoadhesive controlled-release drug formulation. The released amount and effectiveness of the antibacterial properties of the formulations were determined in in vivo and in vitro studies. In laboratory studies, nearly 40% of the total amount of the drug was released over 4 h. Clinically, first day results up to 4 h showed a statistically significant reduction of the bacterial amount in the drug-loaded side of oral mucosa. The results for 1 and 4 days were not statistically significant in the tablet group. The usefulness of the tablet dosage form was also assessed in the subjects.