Microbiological and clinical comparison of chlorhexidine buccoadhesive tablet and chlorhexidine mouthrinse


AKTAŞ A. , GIRAY B., ÇAPAN Y. , MENEMENLIOGLU D. , HAYRAN M. , IKINCI G. , ...More

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.19, no.5, pp.353-357, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 5
  • Publication Date: 2009
  • Doi Number: 10.1016/s1773-2247(09)50073-1
  • Title of Journal : JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Page Numbers: pp.353-357

Abstract

Chlorhexidine, which is a gold standard for antiplaque agents, was prepared (is a buccoadhesive controlled-release drug formulation. The released amount and effectiveness of the antibacterial properties of the formulations were determined in in vivo and in vitro studies. In laboratory studies, nearly 40% of the total amount of the drug was released over 4 h. Clinically, first day results up to 4 h showed a statistically significant reduction of the bacterial amount in the drug-loaded side of oral mucosa. The results for 1 and 4 days were not statistically significant in the tablet group. The usefulness of the tablet dosage form was also assessed in the subjects.