Synthesis and antidiabetic activity of morpholinothiazolyl-2,4-thiazolidindione derivatives

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Ezer M., YILDIRIM L., Bayro O., Verspohl E. J., DÜNDAR O.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.27, sa.3, ss.419-427, 2012 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 27 Sayı: 3
• Basım Tarihi: 2012
• Doi Numarası: 10.3109/14756366.2011.594047
• Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.419-427
• Hacettepe Üniversitesi Adresli: Evet

Özet

We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2,4-thiazolidinediones (1-15). Compounds 5, 11-15 (at lower concentration; 0.001 mg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. The compounds, except derivative 3 show an increase of glucose uptake. Various compounds are interesting potential antidiabetic leads showing pancreatic and extrapancreatic effects.