Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression

Kocaturk, BEGÜM; Tieken, C.; Vreeken, D.; Unlu, B.; Engels, C.; de Kruijf, E.; Kuppen, P.; Reitsma, P.; Bogdanov, V.; Versteeg, H.

doi:10.1111/jth.13049

Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression

Atıf İçin Kopyala

Kocaturk B. , Tieken C., Vreeken D., Unlu B., Engels C. C. , de Kruijf E. M. , ...Daha Fazla

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, cilt.13, ss.1683-1693, 2015 (SCI İndekslerine Giren Dergi)

Cilt numarası: 13 Konu: 9
Basım Tarihi: 2015
Doi Numarası: 10.1111/jth.13049
Dergi Adı: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Sayfa Sayıları: ss.1683-1693

Özet

BackgroundProcoagulant full-length tissue factor (flTF) and its minimally coagulant alternatively spliced isoform (asTF), promote breast cancer (BrCa) progression via different mechanisms. We previously showed that flTF and asTF are expressed by BrCa cells, resulting in autoregulation in a cancer milieu. BrCa cells often express hormone receptors such as the estrogen receptor (ER), leading to the formation of hormone-regulated cell populations.