Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression


Kocaturk B. , Tieken C., Vreeken D., Unlu B., Engels C. C. , de Kruijf E. M. , ...More

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol.13, no.9, pp.1683-1693, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.1111/jth.13049
  • Title of Journal : JOURNAL OF THROMBOSIS AND HAEMOSTASIS
  • Page Numbers: pp.1683-1693

Abstract

BackgroundProcoagulant full-length tissue factor (flTF) and its minimally coagulant alternatively spliced isoform (asTF), promote breast cancer (BrCa) progression via different mechanisms. We previously showed that flTF and asTF are expressed by BrCa cells, resulting in autoregulation in a cancer milieu. BrCa cells often express hormone receptors such as the estrogen receptor (ER), leading to the formation of hormone-regulated cell populations.