Development of oral aprepitant-loaded chitosan-polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation


Erdogar N. , Akkin S., Nielsen T. T. , Ozcelebi E., Erdogdu B., NEMUTLU E. , ...More

JOURNAL OF PHARMACEUTICAL INVESTIGATION, vol.51, no.3, pp.297-310, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1007/s40005-020-00511-x
  • Title of Journal : JOURNAL OF PHARMACEUTICAL INVESTIGATION
  • Page Numbers: pp.297-310

Abstract

Purpose Aprepitant (APRT), a selective neurokinin 1 antagonist, is clinically used in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. The low solubility of APRT, which limits its oral bioavailability, is overcome by nanonization. This study aimed to design and evaluate novel in vitro and in vivo chitosan (CS)-polyethylene glycol (PEG)-coated cyclodextrin (CD) nanoparticles and nanocapsules to enhance the solubility and oral bioavailability of APRT.