Development of oral aprepitant-loaded chitosan-polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation

Erdogar, NAZLI; Akkin, Safiye; Nielsen, Thorbjorn; Ozcelebi, Esin; Erdogdu, Batuhan; NEMUTLU, EMİRHAN; Iskit, Alper; BİLENSOY, EREM

doi:10.1007/s40005-020-00511-x

Development of oral aprepitant-loaded chitosan-polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation

Atıf İçin Kopyala

Erdogar N., Akkin S., Nielsen T. T., Ozcelebi E., Erdogdu B., NEMUTLU E., ...Daha Fazla

JOURNAL OF PHARMACEUTICAL INVESTIGATION, cilt.51, sa.3, ss.297-310, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 51 Sayı: 3
Basım Tarihi: 2021
Doi Numarası: 10.1007/s40005-020-00511-x
Dergi Adı: JOURNAL OF PHARMACEUTICAL INVESTIGATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
Sayfa Sayıları: ss.297-310
Anahtar Kelimeler: Aprepitant, Nanoparticle, Nanocapsule, Amphiphilic cyclodextrin, Neurokinin-1 receptor antagonist, Chemotherapy-induced nausea and vomiting
Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose Aprepitant (APRT), a selective neurokinin 1 antagonist, is clinically used in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. The low solubility of APRT, which limits its oral bioavailability, is overcome by nanonization. This study aimed to design and evaluate novel in vitro and in vivo chitosan (CS)-polyethylene glycol (PEG)-coated cyclodextrin (CD) nanoparticles and nanocapsules to enhance the solubility and oral bioavailability of APRT.