Development of oral aprepitant-loaded chitosan-polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation


Erdogar N. , Akkin S., Nielsen T. T. , Ozcelebi E., Erdogdu B., NEMUTLU E. , ...Daha Fazla

JOURNAL OF PHARMACEUTICAL INVESTIGATION, cilt.51, sa.3, ss.297-310, 2021 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Konu: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s40005-020-00511-x
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL INVESTIGATION
  • Sayfa Sayıları: ss.297-310

Özet

Purpose Aprepitant (APRT), a selective neurokinin 1 antagonist, is clinically used in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. The low solubility of APRT, which limits its oral bioavailability, is overcome by nanonization. This study aimed to design and evaluate novel in vitro and in vivo chitosan (CS)-polyethylene glycol (PEG)-coated cyclodextrin (CD) nanoparticles and nanocapsules to enhance the solubility and oral bioavailability of APRT.