Interleukin-12 (-1188) A/C and interferon-gamma (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients

Dundar N. O., Gencpinar P., Sallakci N., DUMAN Ö., HASPOLAT Ş., Anlar B., ...More

JOURNAL OF NEUROVIROLOGY, vol.22, no.5, pp.661-665, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1007/s13365-016-0442-7
  • Journal Name: JOURNAL OF NEUROVIROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.661-665
  • Hacettepe University Affiliated: Yes

Abstract

The two polymorphisms [IL-12 (-1188) A/C and the IFN-gamma (+874) A/T)] are known to have functional consequences and henceforth were analyzed in subacute sclerosing panencephalitis (SSPE) patients to reveal a possible relation with these polymorphisms and this debilitating disease. For the IL-12 (-1188) A/C polymorphism, 78 patients and 90 healthy individuals were analyzed. An increase in the AA genotype was determined (p = 0.02, OR = 2.06). There was also a statistically significant difference between the control group and the patients with respect to the allele frequencies (p = 0.04, OR = 1.65). For the IFN-gamma (+874) A/T polymorphism, 69 SSPE patients and 115 controls were studied and there was not a significant difference between the two groups. Our findings suggested that not the IFN-gamma (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with SSPE and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.