Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct compression and lyophilization methods


AKDAĞ ÇAYLI Y. , GÜLSÜN İNAL T. , İZAT N. , ÇETİN M., ÖNER L. , ŞAHİN S.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.57, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jddst.2020.101760
  • Title of Journal : JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Abstract

Objectives: The aim of this study was to develop direct compressed and lyophilized fast disintegrating/dissolving tablets (FDTs) that enhanced disintegration and dissolution of deferasirox, a drug with poor solubility and bioavailability. Although there are conventional oral tablets and tablets for oral suspension of deferasirox in the market, deferasirox oral FDTs are not yet available in the market and under investigation.