Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct compression and lyophilization methods

AKDAĞ ÇAYLI Y., GÜLSÜN İNAL T., İZAT N., ÇETİN M., ÖNER L., ŞAHİN S.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.57, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jddst.2020.101760
  • Journal Name: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE
  • Keywords: Fast disintegrating tablets, Deferasirox, Direct compression, Lyophilization, Permeability, IN-VITRO PERMEABILITY, ABSORPTION, FORMULATION, FORMS
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: The aim of this study was to develop direct compressed and lyophilized fast disintegrating/dissolving tablets (FDTs) that enhanced disintegration and dissolution of deferasirox, a drug with poor solubility and bioavailability. Although there are conventional oral tablets and tablets for oral suspension of deferasirox in the market, deferasirox oral FDTs are not yet available in the market and under investigation.