Nutmeg nutraceutical constituents: In vitro and in vivo pharmacological potential

Malik T., Sharma R., Panesar P. S., Gehlot R., TOKUŞOĞLU Ö., Dhull S. B., ...More

JOURNAL OF FOOD PROCESSING AND PRESERVATION, vol.46, no.6, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.1111/jfpp.15848
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, CAB Abstracts, Compendex, Food Science & Technology Abstracts, INSPEC, Veterinary Science Database
  • Hacettepe University Affiliated: Yes


Spices consumptions are in direct relation with the healthy survivability of consumers throughout life as they are loaded with lists of phytoconstituents of human values. Nutmeg owes to its essential, volatile, and fixed oil is in prime most interest by researchers to explore for its benefits through food utilization. Besides being loaded with these phytochemical-based benefit traits it is also rich on the mineral side preferably with potassium, magnesium, and phosphorous. As for as the oil variation is concern, nutmeg essential oil composition behaves as per the geographical and varietal factors. Its beneficial aspect highlighted wherein oil of nutmeg contains Myristicin (phenylpropene organic compound) can exhibit anti-inflammatory response and have the cytotoxic activity against human colorectal carcinoma (HCT-116) and human breast carcinoma Michigan Cancer Foundation (MCF-7). Associated benefits of being on antiangiogenic compounds such as myristicin in Myristica fragrans essential oil resulted in antiangiogenic activity with an IC50 of 77.64 g/ml. Practical applications Nutmeg has its wider acceptability among medicinal and therapeutic uses in today's world. Indeed, many would say that nutmeg use has increased. Nutmeg's traditional applications in treating stomach conditions, curing rheumatic pain, soothing skin wounds and illnesses, and acting as a relaxing agent have resulted in extensive research into its various extracts and fractions. One of the most commonly observed habits is the influence of nutmeg essential oil and extracts on the central nervous system. Nutmeg acetone extract's antioxidant and antimicrobial properties can help to prevent or delay oxidative stress-related diseases and infections caused by opportunistic pathogenic microorganisms. Nutmeg requires further work on several fronts, including the advancement of analytical approaches, reproducible separation procedures, and successful synthetic methods for promising secondary metabolites, as a source of complex secondary metabolites with substantial potential as prototype agents for drug testing.