Effects of physical therapy interventions on pharmacokinetic parameters Farmakokinetik parametreler uzerine fizyoterapi uygulamalarinin etkileri

ŞAHİN S., Yakut E.

Fabad Journal of Pharmaceutical Sciences, vol.25, no.2, pp.75-82, 2000 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 25 Issue: 2
  • Publication Date: 2000
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.75-82
  • Keywords: Exercise, Pharmacokinetics, Physiotherapy
  • Hacettepe University Affiliated: Yes


Most studies on drugs have been performed in subjects at rest. However, little is known how the pharmacokinetics of a drug is influenced by exercise, application of physical agents and massage. These interventions may produce hemodynamic and physiological changes that can potentially alter drug disposition within the body. Physical therapy interventions seem to have the greatest potential to affect absorption and distribution of drugs that are administered by transdermal techniques or by subcutaneous and intramuscular injections. Therefore, physical therapists should also realize that medications can have positive therapeutic effects and adverse side effects that can influence the patient's response to physical therapy. The aim of this article is to discuss how physical therapy interventions can affect the pharmacokinetics of various medications, and how the clinical effects of these medications are affected by altered drug disposition.