COVID-19 vaccination and thyroiditis


Best Practice and Research: Clinical Endocrinology and Metabolism, vol.37, no.4, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 37 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1016/j.beem.2023.101759
  • Journal Name: Best Practice and Research: Clinical Endocrinology and Metabolism
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: COVID-19, Graves’ disease, Hashimoto thyroiditis, painless thyroiditis, SARS-CoV-2, subacute thyroiditis, thyroiditis, vaccination, vaccine
  • Hacettepe University Affiliated: Yes


At the end of 2019, the world began to fight the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2. Many vaccines have quickly been developed to control the epidemic, and with the widespread use of vaccines globally, several vaccine-related adverse events have been reported. This review mainly focused on COVID-19 vaccination-associated thyroiditis and summarized the current evidence regarding vaccine-induced subacute thyroiditis, silent thyroiditis, Graves’ disease, and Graves’ orbitopathy. The main clinical characteristics of each specific disease were outlined, and possible pathophysiological mechanisms were discussed. Finally, areas lacking evidence were specified, and a research agenda was proposed.