Prodrug Polymeric Nanoconjugates Encapsulating Gold Nanoparticles for Enhanced X-Ray Radiation Therapy in Breast Cancer

Nosrati H., Seidi F., Hosseinmirzaei A., Mousazadeh N., Mohammadi A., Ghaffarlou M., ...More

ADVANCED HEALTHCARE MATERIALS, vol.11, no.3, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1002/adhm.202102321
  • Journal Name: ADVANCED HEALTHCARE MATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, Chemical Abstracts Core, Compendex, EMBASE, INSPEC, MEDLINE
  • Keywords: chemoradiation therapy, drug conjugates, gold nanoparticles, high-Z nanoparticles, radiosensitizers, HEART-DISEASE, LUNG-CANCER, CURCUMIN, RADIOTHERAPY, APOPTOSIS
  • Hacettepe University Affiliated: Yes

Abstract

An optimal radiosensitizer with improved tumor retention has an important effect on tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug-containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) are developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy is improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer.