Prodrug Polymeric Nanoconjugates Encapsulating Gold Nanoparticles for Enhanced X-Ray Radiation Therapy in Breast Cancer
ADVANCED HEALTHCARE MATERIALS, cilt.11, sa.3, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 3
- Basım Tarihi: 2022
- Doi Numarası: 10.1002/adhm.202102321
- Dergi Adı: ADVANCED HEALTHCARE MATERIALS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, Chemical Abstracts Core, Compendex, EMBASE, INSPEC, MEDLINE
- Anahtar Kelimeler: chemoradiation therapy, drug conjugates, gold nanoparticles, high-Z nanoparticles, radiosensitizers, HEART-DISEASE, LUNG-CANCER, CURCUMIN, RADIOTHERAPY, APOPTOSIS
- Hacettepe Üniversitesi Adresli: Evet
Özet
An optimal radiosensitizer with improved tumor retention has an important effect on tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug-containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) are developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy is improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer.