Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli

Schumacher, A; Steinke, P; Bohnert, JA; Akova, M; Jonas, D; Kern, WV

doi:10.1093/jac/dki446

Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli

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Schumacher A., Steinke P., Bohnert J., Akova M., Jonas D., Kern W.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol.57, no.2, pp.344-348, 2006 (SCI-Expanded)

Publication Type: Article / Article
Volume: 57 Issue: 2
Publication Date: 2006
Doi Number: 10.1093/jac/dki446
Journal Name: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.344-348
Hacettepe University Affiliated: No

Abstract

Objectives: 1-(1-Naphthylmethyl)-piperazine (NMP) has been shown to reverse multidrug resistance (MDR) in Escherichia coli overexpressing RND type efflux pumps, but there is no data on its activity in Enterobacteriaceae other than E. coli.