Protective Effect of Antioxidant Vitamins on Red Blood Cell Lipoperoxidation Induced by SO2Inhalation
Journal of Basic and Clinical Physiology and Pharmacology, vol.8, no.1-2, pp.31-44, 1997 (Scopus)
- Publication Type: Article / Article
- Volume: 8 Issue: 1-2
- Publication Date: 1997
- Doi Number: 10.1515/jbcpp.1997.8.1-2.31
- Journal Name: Journal of Basic and Clinical Physiology and Pharmacology
- Journal Indexes: Scopus
- Page Numbers: pp.31-44
- Keywords: erythrocyte, fragility, lipoperoxidation, sulfur dioxide, vitamins
- Hacettepe University Affiliated: Yes
Abstract
The aim of this research was to determine whether administration of antioxidant vitamins can reduce oxidant damage in erythrocytes induced by sulfur dioxide (SO2) inhalation. Meth- and sulfhemoglobin ratios, malonyldialdehyde (MDA) levels, osmotic fragility ratios and hematological parameters of a total of 28 rats were compared. SO2was given at 10 ppm, 1 hour daily, for 45 days in a specially designed chamber. DL-α-Tocopherol acetate (40 mg/kg) and Na-ascorbate (200 mg/kg) treatments, initiated 3 days before SO2exposures, were applied intraperitoneally 3 times a week for 45 days. Meth- and sulfhemoglobin ratios, MDA levels and osmotic fragility ratios were significantly higher in the SO2-treated group (p<0.05). Significant decreases in MDA levels and osmotic fragility ratios were observed in the antioxidant-treated group (p<0.05). SO2inhalation resulted in higher MDA levels and osmotic fragility ratios, which can be reduced by vitamin E+C combination. © 2011 by Walter de Gruyter GmbH & Co. All rights reserved.