Akademik Veri Yönetim Sistemi
Journal of Basic and Clinical Physiology and Pharmacology, cilt.8, sa.1-2, ss.31-44, 1997 (Scopus)
The aim of this research was to determine whether administration of antioxidant vitamins can reduce oxidant damage in erythrocytes induced by sulfur dioxide (SO2) inhalation. Meth- and sulfhemoglobin ratios, malonyldialdehyde (MDA) levels, osmotic fragility ratios and hematological parameters of a total of 28 rats were compared. SO2was given at 10 ppm, 1 hour daily, for 45 days in a specially designed chamber. DL-α-Tocopherol acetate (40 mg/kg) and Na-ascorbate (200 mg/kg) treatments, initiated 3 days before SO2exposures, were applied intraperitoneally 3 times a week for 45 days. Meth- and sulfhemoglobin ratios, MDA levels and osmotic fragility ratios were significantly higher in the SO2-treated group (p<0.05). Significant decreases in MDA levels and osmotic fragility ratios were observed in the antioxidant-treated group (p<0.05). SO2inhalation resulted in higher MDA levels and osmotic fragility ratios, which can be reduced by vitamin E+C combination. © 2011 by Walter de Gruyter GmbH & Co. All rights reserved.