JC polyomavirus replication and associated disease in pediatric renal transplantation: an international CERTAIN Registry study

Hoecker B., Tabatabai J., Schneble L., Oh J., Thiel F., Pape L., ...More

PEDIATRIC NEPHROLOGY, vol.33, no.12, pp.2343-2352, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 12
  • Publication Date: 2018
  • Doi Number: 10.1007/s00467-018-4029-9
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.2343-2352


BackgroundJC polyomavirus (JCPyV)-associated nephropathy (JCPyVAN) is a severe, but rare complication in adult renal transplant (RTx) recipients. Related data in pediatric patients are scarce.MethodsBased on the CERTAIN Registry, we therefore performed a multi-center, retrospective study on the JCPyV antibody status, prevalence of JCPyV replication, and its associated disease in 139 pediatric RTx recipients (mean age, 8.55.3years). JCPyV DNA in plasma and/or urine was measured by quantitative PCR at a median time of 3.2 (IQR, 0.3-8.1) years post-transplant.Results53.2% of patients were JCPyV-seronegative prior to transplantation; younger age was associated with JCPyV seronegativity. 34/139 (24.5%) patients post-transplant showed active JCPyV replication in either urine (22.0%), plasma (13.4%), or both (7.6%). JCPyV viremia occurred significantly (p<0.001) more often in patients with viruria (34.6%) than in those without (7.6%), but 7/118 (5.9%) had isolated viremia. High-level viruria (>10(7)copies/mL) was found in 29.6% of viruric patients. A higher net state of immunosuppression constituted an independent risk factor for JCPyV replication both in urine and plasma (OR 1.2, p<0.02). Male patients tended to have a higher risk of JCPyV viremia than females (OR 4.3, p=0.057). There was one male patient (0.7%) with JCPyVAN 7years post-transplant, which resolved after reduction of immunosuppressive therapy. No patient exhibited progressive multifocal leukoencephalopathy.Conclusions p id= Par4 This first multi-center study on JCPyV in pediatric renal transplant recipients shows that JCPyV replication is common (24.5%), with strong immunosuppression being a significant risk factor, but associated nephropathy is rare.