Current Animal Models Used in Migraine Research Migren Araştırmalarında Kullanılan Güncel Hayvan Modelleri

Kaya M. Z., Bozdağ Pehlivan S., ÖNER L.

Hacettepe University Journal of the Faculty of Pharmacy, vol.43, no.4, pp.364-379, 2023 (Scopus) identifier


Animal models are important research tools used in the study of human diseases and in the development of new therapeutic approaches without the risk of harming humans. Although there is not always one-to-one similarity between the biological activity observed in animal models and that obtained in humans, many drugs and treatments for human diseases are developed under the guidance of animal models. In this context, animal models have been extensively developed in recent years to examine the mechanisms of headache and migraine, and as a result, important steps have been taken in the understanding of migraine and the development of anti-migraine treatments. These models include mouse and rat models created by genetic modifications, models that mimic trigeminal nervous system activation, and models that induce headaches with inflammatory agents. Since each model has its own advantages and limitations, the selection of the appropriate animal model to evaluate drug efficacy and the most appropriate experimental method to evaluate the results is a critical parameter. In this review, in-vivo migraine models that have been studied extensively in recent years and the latest findings from these models will be discussed.