Role of gastrointestinal system on transmission and pathogenesis of SARS-CoV-2

ŞİMŞEK C., Erul E., BALABAN H. Y.

WORLD JOURNAL OF CLINICAL CASES, cilt.9, sa.20, ss.5427-5434, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 20
  • Basım Tarihi: 2021
  • Doi Numarası: 10.12998/wjcc.v9.i20.5427
  • Dergi Adı: WORLD JOURNAL OF CLINICAL CASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Sayfa Sayıları: ss.5427-5434
  • Anahtar Kelimeler: SARS-CoV-2, COVID-19, Gastrointestinal system, Transmission, Pathogenesis, RESPIRATORY SYNDROME, GASTRITIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Coronavirus disease 2019 (COVID-19) continues to pose a significant threat to global health. Primary prevention remains as a major strategy against the pandemic. Current evidence proves that aerosol and droplet-based routes are the main means of transmission of COVID-19 but other ways should be sought in order to prevent possible collateral transmission. The gastrointestinal system may be one such route. Angiotensin converting enzyme 2 is the target entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is abundantly expressed in the gastrointestinal tract. SARS-CoV-2 is able to infect human enterocytes similar to severe acute respiratory syndrome and Middle Eastern respiratory syndrome. Herein this review, we discuss the current knowledge regarding the role of gastrointestinal transmission in transmission and pathophysiology of COVID-19.