False-positive results of the NMP22 test due to hematuria

Atsu N., Ekici S., Oge O., Ergen A., Hascelik G. , Ozen H.

JOURNAL OF UROLOGY, vol.167, no.2, pp.555-558, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 167 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1016/s0022-5347(01)69084-0
  • Title of Journal : JOURNAL OF UROLOGY
  • Page Numbers: pp.555-558


Purpose: The problem with available markers for bladder cancer is their low specificity and low positive predictive value due to false-positive results. False-positive results of the NMP22 nuclear matrix protein test (Matritech, Cambridge, Massachusetts) are usually observed in some clinical categories that are usually associated with hematuria and pyuria. This problem is especially serious in bladder cancer since 85% of patients present with hematuria. We investigated the effect of the degree of hematuria and pyuria on NMP22 results in an experimental model and human subjects.