False-positive results of the NMP22 test due to hematuria


Atsu N., Ekici S., Oge O., Ergen A., Hascelik G., Ozen H.

JOURNAL OF UROLOGY, cilt.167, sa.2, ss.555-558, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 167 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0022-5347(01)69084-0
  • Dergi Adı: JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.555-558
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: The problem with available markers for bladder cancer is their low specificity and low positive predictive value due to false-positive results. False-positive results of the NMP22 nuclear matrix protein test (Matritech, Cambridge, Massachusetts) are usually observed in some clinical categories that are usually associated with hematuria and pyuria. This problem is especially serious in bladder cancer since 85% of patients present with hematuria. We investigated the effect of the degree of hematuria and pyuria on NMP22 results in an experimental model and human subjects.