CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer


Shehwana H., Keskus A. G. , Ozdemir S. E. , Acikgoz A. A. , Biyik-Sit R., Cagnan I., ...More

CELLULAR ONCOLOGY, vol.44, no.2, pp.453-472, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1007/s13402-020-00581-x
  • Title of Journal : CELLULAR ONCOLOGY
  • Page Numbers: pp.453-472

Abstract

Purpose Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of breast cancer cells. However, modulation of CHRNA5 expression in the context of estrogen signaling and its prognostic implications in breast cancer remained unexplored.