CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer

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Shehwana H., Keskus A. G., Ozdemir S. E., Acikgoz A. A., Biyik-Sit R., Cagnan I., ...More

CELLULAR ONCOLOGY, vol.44, no.2, pp.453-472, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1007/s13402-020-00581-x
  • Journal Name: CELLULAR ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.453-472
  • Keywords: Breast cancer, CHRNA5, Meta-analysis, Co-expression network, Estrogen receptor targets, Estrogen treatment, Prognosis, GENE-EXPRESSION, RECEPTOR-BETA, RESPONSE ELEMENT, MICROARRAY DATA, PROLIFERATION, METAANALYSIS, PROTEIN, TARGET, GROWTH, CELLS
  • Hacettepe University Affiliated: Yes

Abstract

Purpose Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of breast cancer cells. However, modulation of CHRNA5 expression in the context of estrogen signaling and its prognostic implications in breast cancer remained unexplored.