CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer

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Shehwana H., Keskus A. G., Ozdemir S. E., Acikgoz A. A., Biyik-Sit R., Cagnan I., ...Daha Fazla

CELLULAR ONCOLOGY, cilt.44, sa.2, ss.453-472, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s13402-020-00581-x
  • Dergi Adı: CELLULAR ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.453-472
  • Anahtar Kelimeler: Breast cancer, CHRNA5, Meta-analysis, Co-expression network, Estrogen receptor targets, Estrogen treatment, Prognosis, GENE-EXPRESSION, RECEPTOR-BETA, RESPONSE ELEMENT, MICROARRAY DATA, PROLIFERATION, METAANALYSIS, PROTEIN, TARGET, GROWTH, CELLS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of breast cancer cells. However, modulation of CHRNA5 expression in the context of estrogen signaling and its prognostic implications in breast cancer remained unexplored.