A comparative study of treatment for brain edema: Magnesium sulphate versus dexamethasone sodium phosphate

TURKOGLU O. F., EROĞLU H., OKUTAN O., TUN M. K., BODUR E., SARGON M. F., ...Daha Fazla

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.15, sa.1, ss.60-65, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.jocn.2007.03.005
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.60-65
  • Anahtar Kelimeler: brain edema, magnesium sulphate, dexamethasone sodium phosphate, cold injury, ultrastructural grading system, MESSENGER-RNA EXPRESSION, SPINAL-CORD-INJURY, VASCULAR-PERMEABILITY, RAT HIPPOCAMPUS, GLUCOCORTICOIDS MODULATE, NEURONAL APOPTOSIS, ISCHEMIC DAMAGE, TRANSGENIC MICE, COLD INJURY, THERAPY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Treatments for brain edema are important and one of the major options is corticosteroids. Cell membrane stabilization and prevention of formation of free radicals are the main mechanisms of action of steroids in edema treatment. As an alternative therapeutic agent, magnesium sulphate has been used for its neuroprotective effect in various injury models. In our animal model of brain injury, cold has been used in Sprague-Dawley rats. After brain injury, magnesium sulphate (600 mg/kg) or dexamethasone sodium phosphate (0.2 mg/kg) were administered to experimental groups. The degree of brain edema and lipid peroxidation was evaluated using the wet-dry weight method, the determination of malondialdehyde (MDA) levels and an ultrastructural grading system. Magnesium sulphate treatment was found to be the most effective choice due to the absence of side effects and comparable efficacy to corticosteroids. (C) 2007 Elsevier Ltd. All rights reserved.