Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation?


Ozen S., Bakkaloglu A., Yilmaz E., Duzova A., Balci B., Topaloglu R., ...More

The Journal of rheumatology, vol.30, no.9, pp.2014-8, 2003 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 9
  • Publication Date: 2003
  • Journal Name: The Journal of rheumatology
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.2014-8
  • Keywords: familial Mediterranean fever, carrier frequency, juvenile arthritis, BEHCETS-DISEASE, MEFV MUTATIONS, FREQUENCY, CARRIER, FMF, ADVANTAGE, SPECTRUM

Abstract

Objective. To analyze 70 individuals who were found to have the Mediterranean fever (MEFV) gene for the presence of definite familial Mediterranean fever (FMF) and to assess if they were prone to clinical and laboratory inflammation. We also prospectively evaluated 72 patients with childhood rheumatic diseases for the presence of MEFV mutations.