Therapeutic efficacy of folate receptor-targeted amphiphilic cyclodextrin nanoparticles as a novel vehicle for paclitaxel delivery in breast cancer

ERDOĞAR N., ESENDAĞLI G., Nielsen T. T. , Esendagli-Yilmaz G., Yoyen-Ermis D., Erdogdu B., ...More

JOURNAL OF DRUG TARGETING, vol.26, no.1, pp.66-74, 2018 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1080/1061186x.2017.1339194
  • Journal Name: JOURNAL OF DRUG TARGETING
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.66-74
  • Keywords: Paclitaxel, nanoparticle, folate, amphiphilic cyclodextrin, breast cancer, IN-VIVO EVALUATION, DRUG-DELIVERY, CARBON NANOTUBES, TAXOL, FORMULATION, CELLS, VITRO, RELEASE, CAMPTOTHECIN, CHEMOTHERAPY

Abstract

Purpose: The aim of this study is to test folate-conjugated cyclodextrin nanoparticles (FCD-1 and FCD-2) as a vehicle for reducing toxicity and increasing the antitumor efficacy of paclitaxel especially for metastatic breast cancer.