Background/purpose: Regenerative approaches in endodontics are considered in two concepts. One is a revascularization approach to achieve continued apical formation while the other involves the pulp/dentin regeneration via tissue engineering technology. Recently, some case reports have shown that infected immature teeth can be treated by revascularization approach. However, there is still no standardized treatment protocol for this procedure. The purpose of this review article was to evaluate the effects of regenerative endodontic treatment for necrotic immature permanent teeth and to discuss recent treatment approaches.