Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations


Yasar U. , Aklillu E., Canaparo R., Sandberg M., Sayi J., Roh H., ...Daha Fazla

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, cilt.58, ss.555-558, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 58 Konu: 8
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s00228-002-0518-6
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Sayfa Sayıları: ss.555-558

Özet

Objectives: CYP2C9 is a polymorphic gene with at least six known allelic variants (CYP2C9*1 to *6). CYP2C9*5 has been recently described in African-Americans. The lower activity of CYP2C9*5 encoded enzyme than *1 has been reported for the S-warfarin 7-hydroxylation in vitro. The aim of the present study was to develop an assay for the analysis of this variant and to determine the frequency of this polymorphism in different ethnic populations.