Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations


Yasar U., Aklillu E., Canaparo R., Sandberg M., Sayi J., Roh H., ...More

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, vol.58, no.8, pp.555-558, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 8
  • Publication Date: 2002
  • Doi Number: 10.1007/s00228-002-0518-6
  • Title of Journal : EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Page Numbers: pp.555-558

Abstract

Objectives: CYP2C9 is a polymorphic gene with at least six known allelic variants (CYP2C9*1 to *6). CYP2C9*5 has been recently described in African-Americans. The lower activity of CYP2C9*5 encoded enzyme than *1 has been reported for the S-warfarin 7-hydroxylation in vitro. The aim of the present study was to develop an assay for the analysis of this variant and to determine the frequency of this polymorphism in different ethnic populations.