Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations


Yasar U., Aklillu E., Canaparo R., Sandberg M., Sayi J., Roh H., ...Daha Fazla

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, cilt.58, sa.8, ss.555-558, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 8
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s00228-002-0518-6
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.555-558
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Objectives: CYP2C9 is a polymorphic gene with at least six known allelic variants (CYP2C9*1 to *6). CYP2C9*5 has been recently described in African-Americans. The lower activity of CYP2C9*5 encoded enzyme than *1 has been reported for the S-warfarin 7-hydroxylation in vitro. The aim of the present study was to develop an assay for the analysis of this variant and to determine the frequency of this polymorphism in different ethnic populations.