Occupational hypersensitivity pneumonitis: A preventable cause of interstitial lung disease Mesleki hipersensitivite pnömonisi: Önlenebilir bir interstisyel akciğer hastalığı nedeni
Tuberkuloz ve Toraks, cilt.74, sa.3, ss.174-185, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 74 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.5578/tt.2026031174
- Dergi Adı: Tuberkuloz ve Toraks
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.174-185
- Anahtar Kelimeler: Hypersensitivity pneumonitis, interstitial lung disease, metalworking fluids, occupational hypersensitivity pneumonitis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Hacettepe Üniversitesi Adresli: Evet
Özet
Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease caused by repeated inhalation of organic or chemical antigens, commonly in occupational settings. Although often less severe than other respiratory dise-ases, HP can progress to irreversible pulmonary fibrosis if not diagnosed early. Diagnosis involves a detailed occupational history, high-resolution computed tomography, pulmonary function tests, bronchoalveolar lavage, and immunolo-gic assays. High-risk occupations include farming, bird breeding, poultry proces-sing, wood and textile work, mushroom and compost handling, and healthcare. Notably, exposure to metalworking fluids (MWFs), previously considered rare, has become a prominent cause of HP. MWFs may contain bacteria, fungi, myco-bacteria, and dissolved metals, triggering immune-mediated lung inflammation. Preventive strategies—early recognition, antigen avoidance, and workplace mo-nitoring—are key. Systemic corticosteroids may help in acute stages, but long-term prognosis depends on exposure duration and timely intervention.