Celiac disease in Williams-Beuren syndrome

Simsek-Kiper P. O., Sahin Y., Arslan U., Alanay Y., Boduroglu K., ORHAN D., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.56, sa.2, ss.154-159, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 2
  • Basım Tarihi: 2014
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.154-159
  • Anahtar Kelimeler: Williams-Beuren syndrome, celiac disease, anti-tissue transglutaminase antibodies, anti-endomysium IgA, esophagogastroduodenoscopy, PEDIATRIC-GASTROENTEROLOGY, DERMATITIS-HERPETIFORMIS, CHILDREN, OSTEOPOROSIS, ASSOCIATION, POPULATION, HEPATOLOGY, DIAGNOSIS, NUTRITION, LYMPHOMA
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Celiac disease was previously reported to be frequent among individuals with Williams-Beuren syndrome; however, this suggestion was not investigated further. The present study was conducted to estimate the prevalence of celiac disease in a group of Turkish individuals with Williams-Beuren syndrome (n=33, age range: 1-24 years) by using anti-tissue transglutaminase immunoglobulin (Ig) A and IgG, anti-endomysium IgA, and intestinal biopsy in individuals with positive serology. The prevalence of celiac disease in this population was compared to its prevalence among healthy Turkish schoolchildren. Of all participants, celiac disease was diagnosed in one patient. Although statistically insignificant (p=0.145), the prevalence of celiac disease was higher among individuals with Williams-Beuren syndrome (3%) than among healthy Turkish schoolchildren (0.47%). We recommend questioning individuals with Williams-Beuren syndrome during routine visits regarding celiac disease symptoms and performing serological screening when consistent symptoms are present. Anti-tissue transglutaminase and anti-endomysial antibodies may help to identify those individuals in whom intestinal biopsy is indicated for the diagnosis of celiac disease.