Integration of maternal genome into the neonate genome through breast milk mRNA transcripts and reverse transcriptase


Irmak M. K. , Oztas Y., ÖZTAŞ E.

THEORETICAL BIOLOGY AND MEDICAL MODELLING, cilt.9, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/1742-4682-9-20
  • Dergi Adı: THEORETICAL BIOLOGY AND MEDICAL MODELLING

Özet

Human milk samples contain microvesicles similar to the retroviruses. These microvesicles contain mRNA transcripts and possess reverse transcriptase activity. They contain about 14,000 transcripts representing the milk transcriptome. Microvesicles are also enriched with proteins related to "caveolar-mediated endocytosis signaling" pathway. It has recently been reported that microvesicles could be transferred to other cells by endocytosis and their RNA content can be translated and be functional in their new location. A significant percentage of the mammalian genome appears to be the product of reverse transcription, containing sequences whose characteristics point to RNA as a template precursor. These are mobile elements that move by way of transposition and are called retrotransposons. We thought that retrotransposons may stem from about 14,000 transcriptome of breast milk microvesicles, and reviewed the literature.