IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis

Arthur, Victoria; Shuldiner, Emily; Remmers, Elaine; Hinks, Anne; Grom, Alexei; Foell, Dirk; Martini, Alberto; Gattorno, Marco; ÖZEN, SEZA; Prahalad, Sampath; Zeft, Andrew; Bohnsack, John; Ilowite, Norman; Mellins, Elizabeth; Russo, Ricardo; Len, Claudio; Oliveira, Sheila; Yeung, Rae; Rosenberg, Alan; Wedderburn, Lucy; Anton, Jordi; Haas, Johannes-Peter; Roesen-Wolff, Angela; Minden, Kirsten; Szymanski, Ann; Thomson, Wendy; Kastner, Daniel; Woo, Patricia; Ombrello, Michael

doi:10.1002/art.40498

IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis

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Arthur V. L., Shuldiner E., Remmers E. F., Hinks A., Grom A. A., Foell D., ...More

ARTHRITIS & RHEUMATOLOGY, vol.70, no.8, pp.1319-1330, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 70 Issue: 8
Publication Date: 2018
Doi Number: 10.1002/art.40498
Journal Name: ARTHRITIS & RHEUMATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1319-1330
Hacettepe University Affiliated: Yes

Abstract

Objective. To determine whether systemic juvenile idiopathic arthritis (JIA) susceptibility loci that were identified by candidate gene studies demonstrate association with systemic JIA in the largest study population assembled to date.